Somavert

Generic Name: pegvisomant (Subcutaneous route)

peg-VI-soe-mant

Commonly used brand name(s)

In the U.S.

• Somavert

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Endocrine-Metabolic Agent

Pharmacologic Class: Growth Hormone Receptor Antagonist

Uses For Somavert

Pegvisomant is used to treat a condition called acromegaly, which is caused by too much growth hormone in the body, in patients who cannot be treated with surgery or radiation. Too much growth hormone produced in adults causes the hands, feet, and parts of the face to become large, thick, and bulky. Other problems such as arthritis also can develop. Pegvisomant works by binding to the growth hormone receptor and preventing the actions of too much growth hormone .

This medicine is available only with your doctor's prescription.

Before Using Somavert

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of pegvisomant in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pegvisomant in the elderly. However, elderly patients are more likely to have age-related heart, liver, or kidney problems which may require an adjustment of dose in patients receiving pegvisomant .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Octreotide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Diabetes—Use with caution. May cause changes in the blood sugar .

• Kidney disease or


• Liver disease, or a history of—Use with caution. The effects may be increased because of slower removal of the medicine from the body .

• Tumors that produce growth hormone—Use with caution. May increase risks for more serious side effects .

Proper Use of Somavert

This medicine is given as a shot under your skin. Pegvisomant may sometimes be given at home to patients who do not need to be in the hospital. If you are using this medicine at home, your doctor will teach you how to prepare and inject the medicine. Be sure that you understand exactly how the medicine is prepared and injected .

You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections. Do not inject on an area that has a rash, bruise, lump, or a broken skin .

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:
  
  • For treating acromegaly:
    
    • Adults—At first, 40 milligrams (mg) will be injected under your skin by your doctor. Then, you will inject the next doses of 10 milligrams (mg) once a day under your skin . Higher doses may be needed, as determined by your doctor.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store unopened vials of this medicine in the refrigerator. Do not freeze. Store the medicine that has been mixed at room temperature and use it within 6 hours. Throw away any mixed medicine that has not been used within this time. Do not freeze the solution .

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets .

Precautions While Using Somavert

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects .

Liver problems may occur while you are using this medicine. Stop using this medicine and check with your doctor right away if you are having more than one of these symptoms: abdominal pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin .

The cover of the vials of this medicine contains latex, which may cause allergic reactions in people who are sensitive to latex. Tell your doctor if you have a latex allergy before you start using this medicine .

Make sure your doctor knows if you are using this medicine before taking any tests. This medicine may affect the results of some medical tests (e.g., liver tests), especially if you also use other medicines to treat acromegaly (e.g., octreotide, Sandostatin®) .

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements .

Somavert Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Bleeding, blistering, burning, coldness, or discoloration of skin at site of injection


• bloating or swelling of face, arms, hands, lower legs, or feet


• blurred vision


• chest pain


• chills


• cough


• dizziness


• feeling of pressure


• fever


• headache


• hives


• hoarseness


• infection, inflammation, itching, or lump at site of injection


• nervousness


• lower back or side pain


• painful or difficult urination


• pounding in the ears


• rapid weight gain


• slow or fast heartbeat


• tingling of hands or feet


• unusual weight gain or loss

Less common

• Thickening of the skin

Incidence not known

• Abdominal pain or tenderness


• clay colored stools


• dark urine


• decreased appetite


• fever


• itching


• loss of appetite


• nausea and vomiting


• skin rash


• unusual tiredness or weakness


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Accidental injury


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• diarrhea


• general feeling of discomfort or illness


• joint pain


• muscle aches and pains


• pain


• pain or tenderness around eyes and cheekbones


• runny or stuffy nose


• shivering


• shortness of breath or troubled breathing


• sore throat


• sweating


• tightness of chest or wheezing


• trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Somavert side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Somavert resources

• Somavert Side Effects (in more detail)
• Somavert Use in Pregnancy & Breastfeeding
• Somavert Drug Interactions
• Somavert Support Group
• 1 Review for Somavert - Add your own review/rating

• Somavert Prescribing Information (FDA)


• Somavert Consumer Overview


• Somavert Monograph (AHFS DI)


• Somavert MedFacts Consumer Leaflet (Wolters Kluwer)


• Pegvisomant Professional Patient Advice (Wolters Kluwer)

Compare Somavert with other medications

• Acromegaly

Zapzyt Cleansing Topical

Generic Name: sulfur (Topical route)

SUL-fur

Commonly used brand name(s)

In the U.S.

• Liquimat


• Sastid Soap


• Sulfoam


• Sulfo-Lo


• Sulmasque


• Sulpho-Lac


• Sul-Ray Aloe Vera Acne


• Thylox Acne Treatment


• Zapzyt Cleansing

Available Dosage Forms:

• Soap


• Ointment


• Shampoo


• Liquid


• Lotion


• Cream


• Gel/Jelly


• Solution

Therapeutic Class: Antiacne

Uses For Zapzyt Cleansing

Sulfur is used to treat many kinds of skin disorders. Sulfur cream, lotion, ointment, and bar soap are used to treat acne. Sulfur ointment is used to treat seborrheic dermatitis and scabies. Sulfur may also be used for other conditions as determined by your doctor.

Some of these preparations are available only with your doctor's prescription.

Before Using Zapzyt Cleansing

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of this medicine in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. Although there is no specific information comparing use of sulfur in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of sulfur

This section provides information on the proper use of a number of products that contain sulfur. It may not be specific to Zapzyt Cleansing. Please read with care.

Use this medicine only as directed. Do not use it more often and do not use it for a longer period of time than recommended on the label, unless otherwise directed by your doctor.

Keep this medicine away from the eyes. If you should accidentally get some in your eyes, flush them thoroughly with water.

To use the cream or lotion form of this medicine:

• Before applying the medicine, wash the affected areas with soap and water and dry thoroughly. Then apply enough medicine to cover the affected areas and rub in gently.

To use the ointment form of this medicine for seborrheic dermatitis:

• Before applying the medicine, wash the affected areas with soap and water and dry thoroughly. Then apply enough medicine to cover the affected areas and rub in gently.

To use the ointment form of this medicine for scabies:

• Before applying the medicine, wash your entire body with soap and water and dry thoroughly.


• At bedtime, apply enough medicine to cover your entire body from the neck down and rub in gently. Leave the medicine on your body for 24 hours.


• Before applying the medicine again, you may wash your entire body.


• 24 hours after the last treatment with this medicine, it is important that you thoroughly wash your entire body again.

To use the soap form of this medicine:

• Work up a rich lather with the soap, using warm water. Wash the affected areas and rinse thoroughly. Apply again, and rub in gently for a few minutes. Remove excess lather with a towel or tissue without rinsing.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For acne:
  
  • For cream and bar soap dosage forms:
    
    • Adults and children—Use on the skin as needed.
    
    
  
  
  • For lotion dosage form:
    
    • Adults and children—Use two or three times a day.
    
    
  
  
  • For ointment dosage form:
    
    • Adults and children—Use the 0.5% ointment on the skin as needed.
    
    
  
  


• For seborrheic dermatitis:
  
  • For ointment dosage form:
    
    • Adults and children—Use the 5 to 10% ointment one or two times a day.
    
    
  
  


• For scabies:
  
  • For ointment dosage form:
    
    • Adults and children—Use the 6% ointment each night for three nights.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Zapzyt Cleansing

When using sulfur, do not use any of the following preparations on the same affected area as this medicine, unless otherwise directed by your doctor:

• Abrasive soaps or cleansers


• Alcohol-containing preparations


• Any other topical acne preparation or preparation containing a peeling agent (for example, benzoyl peroxide, resorcinol, salicylic acid, or tretinoin [vitamin A acid])


• Cosmetics or soaps that dry the skin


• Medicated cosmetics


• Other topical medicine for the skin

To use any of the above preparations on the same affected area as sulfur may cause severe irritation of the skin.

Do not use any topical mercury-containing preparation, such as ammoniated mercury ointment, on the same area as this medicine. To do so may cause a foul odor, may be irritating to the skin, and may stain the skin black. If you have any questions about this, check with your health care professional.

Zapzyt Cleansing Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• Skin irritation not present before use of this medicine

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Redness and peeling of skin (may occur after a few days)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Zapzyt Cleansing Topical side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Zapzyt Cleansing Topical resources

• Zapzyt Cleansing Topical Side Effects (in more detail)
• Zapzyt Cleansing Topical Use in Pregnancy & Breastfeeding
• Zapzyt Cleansing Topical Drug Interactions
• Zapzyt Cleansing Topical Support Group
• 1 Review for Zapzyt Cleansing Topical - Add your own review/rating

Compare Zapzyt Cleansing Topical with other medications

• Acne

Tyvaso Refill Kit

Generic Name: treprostinil inhalation (tre PROS ti nil)

Brand Names: Tyvaso, Tyvaso Refill Kit, Tyvaso Starter Kit

What is Tyvaso Refill Kit (treprostinil inhalation)?

Treprostinil works by dilating (widening) blood vessels in your lungs and by keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots. These effects lower blood pressure in the pulmonary artery that leads from your heart to your lungs.

Treprostinil is used to treat pulmonary arterial hypertension (PAH). It improves your ability to exercise and prevents your condition from getting worse.

Treprostinil may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Tyvaso Refill Kit (treprostinil inhalation)?

Before using this medication, tell your doctor if you have a breathing disorder such as asthma or COPD (chronic obstructive pulmonary disease), an infection in your lungs (including pneumonia), low blood pressure, liver or kidney disease, or a bleeding or blood clotting disorder.

Treprostinil inhalation should be used only with a Tyvaso inhalation system. The inhalation system comes with patient instructions for safe and effective use. Do not use the medication at home if you do not fully understand how to use the inhalation system and properly clean it daily. Ask your doctor or pharmacist if you have any questions.

The effects of treprostinil inhalation will lessen over time between doses. Talk with your doctor if you need to time your dosing around any planned activities.

It is important to use treprostinil regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. Make sure you have a backup inhalation system available so as not to interrupt your treatment if one system stops working.

Call your doctor if your symptoms do not improve or if they get worse.

What should I discuss with my healthcare provider before using Tyvaso Refill Kit (treprostinil inhalation)?

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication:

• 
  

  a breathing disorder such as asthma or COPD (chronic obstructive pulmonary disease);

  
  


• 
  

  an infection in your lungs, including pneumonia;

  
  


• 
  

  low blood pressure;

  
  


• liver disease;


• kidney disease; or


• 
  

  a bleeding or blood clotting disorder.

  
  

FDA pregnancy category B. It is not known whether this medication is harmful to an unborn baby. Use an effective form of birth control while you are using treprostinil inhalation. Tell your doctor if you become pregnant during treatment. It is not known whether treprostinil passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is treprostinil inhalation given?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label.

Treprostinil inhalation should be used only with a Tyvaso inhalation system. The inhalation system comes with patient instructions for safe and effective use. Do not use the medication at home if you do not fully understand how to use the inhalation system and properly clean it daily. Ask your doctor or pharmacist if you have any questions.

The inhalation form of treprostinil is usually given 4 times per day at evenly spaced intervals during waking hours. Each time you use the medication, you will inhale up to 9 breaths of the medication. Follow your doctor's instructions.

Your doctor may occasionally change your dose to make sure you get the best results from this medication. Most people start treatment with 1 to 3 breaths per treatment session, slowly increasing the number to 9 breaths per session.

Do not use more than 9 breaths per treatment session. Wash your hands before preparing your treprostinil doses in the inhalation system.

One ampule of treprostinil inhalation contains enough medicine for all 4 of a day's doses.

Before your first dose of each day, twist off the top of one ampule and squeeze out the entire contents into the medicine cup of the inhalation system. At the end of the day after the last dose has been given, empty and rinse out the medicine cup, even if there is still unused treprostinil left in it.

To keep the medicine in the cup from spilling, store the inhalation system upright and tightly capped with the plugs when not in use.

The effects of treprostinil inhalation will lessen over time between doses. Talk with your doctor if you need to time your dosing around any planned activities.

Call your doctor if your symptoms do not improve or if they get worse.

It is important to use treprostinil regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. Make sure you have a backup inhalation system available so as not to interrupt your treatment if one system stops working.

Store treprostinil ampules in their foil pouch at room temperature away from moisture, heat, and light. Once you have opened a foil pouch, the ampules in it should be used within 7 days.

Any treprostinil placed into the medicine cup of the inhalation system must be used within 24 hours. Throw away any unused medicine at the end of the day after your last dose.

What happens if I miss a dose?

Call your doctor for instructions.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include flushing (warmth, redness or tingling), headache, nausea, vomiting, diarrhea, feeling light-headed, or fainting.

What should I avoid while using Tyvaso Refill Kit (treprostinil inhalation)?

Avoid getting treprostinil in your eyes or on your skin. If this does happen, rinse with water. Do not swallow treprostinil inhalation. The medication should be inhaled using only the Tyvaso inhalation system. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Tyvaso Refill Kit (treprostinil inhalation) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  new or worsening PAH symptoms such as feeling short of breath (even with mild exertion), tiredness, chest pain, and pale skin;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  fever, chills, cough with yellow or green mucus, stabbing chest pain, wheezing;

  
  


• 
  

  unusual bleeding such as nosebleeds, bleeding gums, or any bleeding that will not stop;

  
  


• 
  

  pale skin, weakness, easy bruising;

  
  


• 
  

  unexpected vaginal bleeding;

  
  


• 
  

  blood in your urine or stools, black or tarry stools;

  
  


• 
  

  coughing up blood or vomit that looks like coffee grounds; or

  
  


• 
  

  swelling of your ankles or feet.

  
  

Less serious side effects may include:

• 
  

  cough, sore throat;

  
  


• 
  

  pain or irritation in your throat after use;

  
  


• 
  

  dizziness;

  
  


• 
  

  nausea, diarrhea;

  
  


• 
  

  headache or jaw pain; or

  
  


• 
  

  flushing (warmth, redness or tingling).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Tyvaso Refill Kit (treprostinil inhalation)?

Before using treprostinil, tell your doctor if you are using any of the following drugs:

• 
  

  gemfibrozil (Lopid);

  
  


• 
  

  delavirdine (Rescriptor);

  
  


• 
  

  nicardipine (Cardene);

  
  


• 
  

  pioglitazone (Actos, ActoPlus Met, Duetact);

  
  


• 
  

  tolbutamide (Orinase);

  
  


• 
  

  an antibiotic such as rifampin (Rifater, Rifadin, Rifamate) or rifapentine (Priftin);

  
  


• 
  

  antifungal medication such as fluconazole (Diflucan), or ketoconazole (Nizoral);

  
  


• 
  

  blood pressure medication;

  
  


• 
  

  a blood thinner such as warfarin (Coumadin).

  
  


• 
  

  a diuretic (water pill);

  
  


• 
  

  medication to treat congestive heart failure, such as hydralazine (Apresoline, BiDil), nesiritide (Natrecor), nitroglycerin, or nitroprusside (Nitropress);

  
  


• 
  

  an NSAID (non-steroidal anti-inflammatory drug) such as flurbiprofen (Ansaid), ibuprofen (Advil, Motrin), indomethacin (Indocin), mefenamic acid (Ponstel), or piroxicam (Feldene);

  
  


• 
  

  seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin) fosphenytoin (Cerebyx), phenobarbital (Solfoton), primidone (Mysoline), or secobarbital (Seconal);or

  
  


• 
  

  sulfa drugs such as sulfisoxazole (Bactrim, Cotrim, Gantanol, Gantrisin, Septra), and others.

  
  

This list is not complete and there may be other drugs that can interact with treprostinil. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Tyvaso Refill Kit resources

• Tyvaso Refill Kit Side Effects (in more detail)
• Tyvaso Refill Kit Use in Pregnancy & Breastfeeding
• Tyvaso Refill Kit Drug Interactions
• Tyvaso Refill Kit Support Group
• 4 Reviews for Tyvaso Refill - Add your own review/rating

• Treprostinil Professional Patient Advice (Wolters Kluwer)


• Treprostinil Inhalation Solution MedFacts Consumer Leaflet (Wolters Kluwer)


• treprostinil Inhalation Advanced Consumer (Micromedex) - Includes Dosage Information


• Remodulin Prescribing Information (FDA)


• Remodulin Solution MedFacts Consumer Leaflet (Wolters Kluwer)


• Remodulin Monograph (AHFS DI)


• Remodulin Advanced Consumer (Micromedex) - Includes Dosage Information


• Tyvaso Prescribing Information (FDA)


• Tyvaso Consumer Overview

Compare Tyvaso Refill Kit with other medications

• Pulmonary Arterial Hypertension

Where can I get more information?

• Your doctor or pharmacist can provide more information about treprostinil inhalation.

See also: Tyvaso Refill side effects (in more detail)

lidocaine Ophthalmic

LYE-doe-kane

Commonly used brand name(s)

In the U.S.

• Akten

Available Dosage Forms:

• Gel/Jelly


• Solution

Therapeutic Class: Anesthetic, Local

Chemical Class: Amino Amide

Uses For lidocaine

Lidocaine belongs to the family of medicines called local anesthetics. lidocaine is applied in the eye to cause numbness or loss of feeling before certain procedures. It works by blocking the signals at the nerve endings in the eye.

lidocaine is available only with your doctor's prescription.

Before Using lidocaine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lidocaine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to lidocaine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies on the relationship of age to the effects of lidocaine ophthalmic gel have not been performed in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lidocaine ophthalmic gel in the elderly.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of lidocaine

A nurse or other trained health professional will give you lidocaine. lidocaine is given by applying the correct number of drops to the surface of your eye in the area of the planned procedure. For most procedures, two drops will be all that is needed. However, for some other procedures, several applications of the medicine may be needed.

Precautions While Using lidocaine

After lidocaine is applied to the eye, do not rub or wipe the eye until the feeling in the eye returns. To do so may cause injury or damage to the eye.

lidocaine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Blurred vision or other changes in vision


• burning feeling at site of application


• redness of the white part of eyes or inside of eyelids

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Headache

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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More lidocaine Ophthalmic resources

• Lidocaine Ophthalmic Use in Pregnancy & Breastfeeding
• Lidocaine Ophthalmic Support Group
• 0 Reviews for Lidocaine Ophthalmic - Add your own review/rating

• Akten Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Akten Consumer Overview

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